By Shayne C. Gad
Acute toxicology trying out offers the 1st defensive position opposed to possibly risky chemical substances. This e-book is a whole and sensible advisor to accomplishing and examining all regulatory required and wide-spread acute toxicity assessments. It provides exact protocols for all the universal try out designs and reports their improvement and pursuits. Acute Toxicology checking out, moment Edition will curiosity not just employees within the pharmaceutical undefined, but additionally researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and examining results
* entire assurance of all significant try designs and their barriers and advantages
* present prestige of other try out designs and versions
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Extra info for Acute Toxicology Testing
Approaches to the prediction of dermal absorption and potential cutaneous toxicity. In Alternative Methods in Toxicology (A. M. ), Vol. 3, pp. 56-536. Liebert, New York. Gad, S. , and Chengelis, C. P. (1988). Acute Toxicity: Principles and Methods. Telfor Press, Caldwell, NJ. Gad, S. , Dunn, B. , Dobbs, D. , and Walsh, R. D. (1986a). Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST). Toxicol Appl. Pharmacol. 84, 93-114. 3 Tests for Dermal Irritation and Corrosion 55 Gad, S.
Observe all animals at 24, 48, and 72 hr after injection. 5. Reclip the fur as necessary during the observation period. If each animal at any observation period shows an average reaction to the test sample that is not significantly greater than that to the blank, the test sample meets the requirements of this test. If at any observation period the average reaction to the test sample is questionably greater than the average reaction to the blank, repeat the test using three additional rabbits. On such a repeat test, the average reaction to the test sample in any of the three animals is not significantly greater than the blank.
Walsh, R. , and Dunn, B. J. (1986b). Correlation of ocular and dermal irritancy of industrial chemicals. Ocular Dermal Toxicol. 5(3), 195-213. Gales, Y. , Gross, C. , Karebs, R. , and Smith, W. J. (1989). Flow cytometric analysis of toxicity by alkylating agents in human epidermal keratinocytes. In In Vitro Toxicology: New Directions (A. M. ), pp. 169-174. Liebert, New York. Gilman, M. R. (1982). Skin and eye testing in animals. In Principles and Methods of Toxicology (A. W. ), pp. 209-222. Raven Press, New York.